THE AUTHOR'S ANSWER TO DISCUSSION BY AKIRA, NAKANISHI : Akira NAKANISHI, J. Archit. Plann. Eng. AIJ, No.564, 377, Feb., 2003

Synthesis of the Nakanishi Ring-Locked Retinoid

An optimized synthetic route to prepare ring-locked retinoid 1a has been developed. We fully describe a purification protocol that provides isomerically pure 1a in support of on-going proof of concept studies for the development of therapeutic agents to treat human ADRP. Additionally, we have found that isomerically pure 1a can be stored in amber vials under argon at -20°C for use over time (up...

AKIRA: a Framework for MABS

Here we present AKIRA, a framework for Agent-based cognitive and social simulations. AKIRA is an open-source project, currently developed mainly at ISTC-CNR, that exploits state-of-the-art techniques and tools. It gives to the programmer a number of facilities for building Agents at different level of complexity (e.g. reactive, deliberative, layered). Here we describe the main architectural fea...

Burnside obstructions to the Montesinos – Nakanishi 3 – move conjecture

Yasutaka Nakanishi asked in 1981 whether a 3–move is an unknotting operation. In Kirby’s problem list, this question is called The Montesinos–Nakanishi 3– move conjecture. We define the nth Burnside group of a link and use the 3rd Burnside group to answer Nakanishi’s question; ie, we show that some links cannot be reduced to trivial links by 3–moves. AMS Classification numbers Primary: 57M27 Se...

Bacteriol . Akira Ishihama and Kazuei Igarashi

Designing and Implementing MABS in AKIRA

Here we present AKIRA, a framework for Agent-based cognitive and social simulations. AKIRA is an open-source project, currently developed mainly at ISTC-CNR, that exploits state-of-the-art techniques and tools. It gives to the programmer a number of facilities for building Agents at different levels of complexity (e.g. reactive, deliberative, layered). Here we describe the main architectural fe...